Why I`m Totally Convinced That The Skull Expansion Hypothesis Is Correct!
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This theory suggests that male pattern hair loss (MPHL) results from an exaggeration of skull bone growth and the formation of ridges (and promontory areas, bumps) along the suture lines of the scalp, with the genetic component being sensitivity to DHT in one or more of the bones of the skull. (I.e. parietal, frontal, occipital bones)
This will turn will trigger a cascade that involves galea aponeurotica/skin tension (1) → inflammation/gradual fibrosis (TGF-b, IL-6 etc.) in the affected region directly above the galea (2) → reduced blood flow to the follicles of the affected region, resulting from the tension directly, and in time from the fibrotic lesions even more so (3) → progressive MPHL.
The catalyst for this process is suggested to be (in most cases) poor insulin sensitivity/metabolic syndrome, (MS) as insulin, IGF-1 and SHBG are all involved in the regulation of androgens/DHT, and those factors are all dysregulated in individuals with degrees of the MS. (4)(5)(6) This in turn could lead to evolutionary novel levels of DHT. Poor insulin sensitivity and the MS resulting from the modern industrial diet and lifestyle could then be said to be the ultimate cause of MPHL. This is corroborated by the observation that only mild post reproductive MPHL is observed in rare cases in wild living humans, (hunter-gatherer`s) as well as in our closest primate relatives. (Chimps and Bonobo`s etc.) Hence younger age, widespread and more severe MPHL could be a form of exaggerated antagonistic pleiotropy, (7) and might be considered a disease of civilization.
-I might also add that you can move a single vellus follicle from the scalp of AGA-prone men and have it grow better than non-AGA follicles, even when controlling for DHT. (8) You are simply removing it from the fibrotic environment. So it`s a question of mechanism here.
-Also, what are the chances that the fact that MPB only happens in the region above the galea, (9) and that the measured tension in the galea/skin above corresponds exactly with both the start of onset and the severity of MPB:) Pretty astronomic odds that this is a coincidence!
-Identical twins do not always have identical patterns of hair loss, indicating epigenetic (environmental) factors. (10)
-Relieving the tension in the galea/skin with either botox or mechanical devices yields some reversal of MPB, similar to that of finasteride in fact. (11)
-There is no mechanism by which DHT action on follicles can produce skin tension, immune activation → fibrosis and reduced blood flow. There has to be an insult to activate the immune system, and skull expansion theory (mechanical challenge) explains that perfectly. This is basic biology. (12)
-Although anecdotal, visual observations of men with more advanced MPB always reveal ridges, bumps and/or enlarged parts of the skull. (Frontal hair loss → big forehead. Most common pattern is the sagittal suture line ridge.) (13) Examples;
Why I`m Totally Convinced That The Skull Expansion Hypothesis Is Correct!
Why I`m Totally Convinced That The Skull Expansion Hypothesis Is Correct!
Why I`m Totally Convinced That The Skull Expansion Hypothesis Is Correct!
This theory suggests that male pattern hair loss (MPHL) results from an exaggeration of skull bone growth and the formation of ridges (and promontory areas, bumps) along the suture lines of the scalp, with the genetic component being sensitivity to DHT in one or more of the bones of the skull. (I.e. parietal, frontal, occipital bones)
This will turn will trigger a cascade that involves galea aponeurotica/skin tension (1) → inflammation/gradual fibrosis (TGF-b, IL-6 etc.) in the affected region directly above the galea (2) → reduced blood flow to the follicles of the affected region, resulting from the tension directly, and in time from the fibrotic lesions even more so (3) → progressive MPHL.
The catalyst for this process is suggested to be (in most cases) poor insulin sensitivity/metabolic syndrome, (MS) as insulin, IGF-1 and SHBG are all involved in the regulation of androgens/DHT, and those factors are all dysregulated in individuals with degrees of the MS. (4) (5) (6) This in turn could lead to evolutionary novel levels of DHT. Poor insulin sensitivity and the MS resulting from the modern industrial diet and lifestyle could then be said to be the ultimate cause of MPHL. This is corroborated by the observation that only mild post reproductive MPHL is observed in rare cases in wild living humans, (hunter-gatherer`s) as well as in our closest primate relatives. (Chimps and Bonobo`s etc.) Hence younger age, widespread and more severe MPHL could be a form of exaggerated antagonistic pleiotropy, (7) and might be considered a disease of civilization.
-I might also add that you can move a single vellus follicle from the scalp of AGA-prone men and have it grow better than non-AGA follicles, even when controlling for DHT. (8) You are simply removing it from the fibrotic environment. So it`s a question of mechanism here.
-Also, what are the chances that the fact that MPB only happens in the region above the galea, (9) and that the measured tension in the galea/skin above corresponds exactly with both the start of onset and the severity of MPB:) Pretty astronomic odds that this is a coincidence!
-Identical twins do not always have identical patterns of hair loss, indicating epigenetic (environmental) factors. (10)
-Relieving the tension in the galea/skin with either botox or mechanical devices yields some reversal of MPB, similar to that of finasteride in fact. (11)
-There is no mechanism by which DHT action on follicles can produce skin tension, immune activation → fibrosis and reduced blood flow. There has to be an insult to activate the immune system, and skull expansion theory (mechanical challenge) explains that perfectly. This is basic biology. (12)
-Although anecdotal, visual observations of men with more advanced MPB always reveal ridges, bumps and/or enlarged parts of the skull. (Frontal hair loss → big forehead. Most common pattern is the sagittal suture line ridge.) (13) Examples;
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